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During surgery patients were categorized as a case or symptomatic control (people with pain but no surgical or pathological evidence of endometriosis) by the gynecological surgeon (NAL), and diagnoses were confirmed by histopathology

Here, elevated NO production as a result of increased activation of NOXs, in particular NOX4 leads to the stabilisation of HIF-1 and thus promotion of endothelial cell (EC) survival, migration, differentiation, and therefore neovascularisation 64,106,107,108

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On the other hand, another study found that 3-month treatment with NR in a PD mouse model resulted in increased NMN and NAD + metabolism marker NAAD but did not increase NAD + levels 287